- integrative genomic approaches identify ikbke as a breast cancer oncogene

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integrative genomic approaches identify ikbke as a breast cancer oncogene -


Integrative Genomic Approaches Identify IKBKE as a Breast Cancer Oncogene. This integrated approach permitted us both to identify IKBKE as a breast cancer oncogene amplified in a significant percentage of human breast tumors and to verify its functional role in mammary cell njwx.info by: Jun 15,  · IKKepsilon activates the nuclear factor-kappaB (NF-kappaB) pathway in both cell lines and breast cancers. These observations suggest a mechanism for NF-kappaB activation in breast cancer, implicate the NF-kappaB pathway as a downstream mediator of PI3K, and provide a framework for integrated genomic approaches in oncogene discovery. PMID: Cited by:

Integrative Genomic Approaches Identify IKBKE as a Breast Cancer Oncogene. This integrated approach permitted us both to identify IKBKE as a breast cancer oncogene amplified in a significant percentage of human breast tumors and to verify its functional role in mammary cell transformation. Similarly, other recent reports highlight the power Cited by: sary for cancer cell viability (Moffat et al., ; Ngo et al., ). In principle, it should be possible to integrate such approaches to develop a framework to identify and vali-date genes critical to cancer development. Here we have applied such an integrative genomic approach to the Ras signaling pathway. The Ras signaling pathway.

We provide a review of each such protein not verified by either of the employed golden standard datasets. IKBKE has been shown to be a breast cancer oncogene via . Integrative Genomic Approaches Identify IKBKE as a Breast Cancer Oncogene. Boehm JS, Zhao JJ, Yao J, Kim SY, Firestein R, Dunn IF, Sjostrom SK, Garraway LA.